By William E. Paul
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Extra resources for Annual Review of Immunology Volume 1 1983
Rev. Immunol. 1:1-33. org by HINARI on 08/27/07. For personal use only. It wasgenerally believed that the reactions weredue to contamination with bacterial protein. Althoughclinicians werepreparedto inject 30 g of dextran intravenously, no one on the committeewouldinject 1 mgto see if it was antigenic. 5 mgof dextran a day apart. tN/ml. At the next meetingof the Subcommittee on Shock, I demonstratedmyprecipitates and also did a skin test on myselfand on DougLawrason,the Secretary of the Committee, as a control.
Most expressed support. Columbia University through Dean Rappleye, Houston Merritt, and Harry Rosesupported meunequivocally. The scientific societies fought the policy vigorously. Michael and manyothers refused to review grant applications. Unfortunately, not all actions were of this type: One person, whomI had considered one of myclosest friends, avoided me and on one occasion even hid in the stacks of the WoodsHole library when he saw me comingtoward him. Abner Wolf, Ada Bezer, and I had to kill off the only~monkeycolony in the world then being devoted to the multiple sclerosis problem.
For personal use only. 46 NOSSAL In later studies, Boyd&Schraderhaveprovidedfurther valuableinsights (14, 15). In the presenceof colchicine, cappingoccurs, presumablyaiding antigen removal. However,in the continued presence of exogenousantigen, colchicine wasnot able to reverse the negative signal, arguingagainst the notionthat colchicine-sensitivestructures, suchas microtubules, are essential for signal transmission. Furthermore, blockade in neonatal AFCcould not be completely reversed by enzymaticremovalof surface antigen.
Annual Review of Immunology Volume 1 1983 by William E. Paul